Pain Crisis 

Sudden, severe pain caused by blocked blood flow or sickled red blood cells 

Shortness of Breath 

Difficulty breathing due to reduced oxygen supply in the bloodstream 

Pale or Yellow Skin  

Skin discoloration indicating anemia or increased breakdown of red blood cells 

Extreme Fatigue 

Persistent tiredness resulting from low hemoglobin or poor oxygen circulation 

Abnormal Red Blood Cells  

Irregular shape or size of red cells affecting proper oxygen transport